Ib lub xovtooj ntawm tes tau hais tias yog homozygous rau ib lub noob tshwj xeeb thaum tib cov alleles ntawm cov noob muaj nyob rau ntawm ob homologous chromosomes.
Humanized nas qauv muaj ntau yam kev siv hauv kev tshawb fawb txog AIDS, mob qog noj ntshav, kab mob sib kis, thiab kab mob ntshav.
Knock-in (KI) yog ib qho txheej txheem uas siv homologous recombination ntawm cov noob los hloov ib qho kev ua haujlwm ntawm cov noob mus rau hauv ib qho homologous nyob rau hauv lub cell thiab genome, thiab tau txais kev qhia zoo nyob rau hauv lub cell tom qab gene recombination.
Conditional Knock-out (CKO) yog cov ntaub so ntswg tshwj xeeb ntawm cov noob caj noob ces ua tiav los ntawm ib qho kev sib koom ua ke hauv zos.
Los ntawm kev thovTurboMice ™thev naus laus zis, peb tuaj yeem tshuaj ntsuam embryonic qia hlwb ncaj qha tom qab gene kho hauv 3-5 hnub, tom qab ntawd tsim lub tetraploid cell, thiab tau homozygous multi-locus gene-edited nas nyob rau hauv 3-5 lub hlis tom qab surrogacy los ntawm niam nas, uas yuav txuag tau 1 xyoo. rau peb cov neeg siv khoom.
TurboMice ™thev naus laus zis ua kom cov noob hloov kho ntawm cov kab ntev ntev tshaj 20kb, yog li ua kom yooj yim rau kev tsim cov qauv nrawm xws li humanization, conditional knockout (CKO), thiab tawg tawg loj (KI).